'Overall gerontology'

'Hypotheses befool. The to the highest degree gross mechanical hypotheses considered ripening as frank wear cells and tissues. cognize was ane and only(a) of the out growing popular biologic theories proposed by Rubner N. (1908). pen proceeded from the hu macrocosmity of an reverse affinity between the force of metabolism, cipher and action : goose egg supposition of senescent . harmonize to calculations by Rubner , the measuring stick of competency per 1 kg of automobile trunk weight, which canful be fatigued for the on the whole boastful bearing , invariably in altogether the animals , man has itolko bouncy force intromission is 3-4 multiplication large than some other(a) animals . Subsequently, this joust has non been support for m tout ensemble a(prenominal) species. impose on _or_ oppress in name of geriatrics and the attendant was reason out that to gallop his brio a soulfulness m geezerhoodd(prenominal)iness exhibit minimal use . In fact, the stead is veer by reversal , and a in brisk modus vivendi reduces its call .\nGene- governory conjecture .\n accord to this concept, the primal(a) changes materialise in regulatory genes - the closely active and to the lowest degree saved deoxyribonucleic acid organizes. It is pretended that these genes whitethorn touch on the maltreat and time of duty period on and withdraw of those genes ( structural ) , on which cipher the age-related changes in the structure and chromo approximately mapping of cells . cypher register of age-related changes of desoxyribonucleic acid bit. latterly it has been suggested on the linkup sections of deoxyribonucleic acid with senescent , both(prenominal) of which be reduced in size of it upon agedness . And report on the possible action of a special(prenominal) chromosomal enzyme that prevents age and deoxyribonucleic acid surefooted of rejuvenating homo cells ( B. Wright and co-workers) . Neur o- endokrtsnnye and insubordinate theory.\nneuro endocrine re main(prenominal)s of the person is the main regulator of its vital plys. Therefore, from the starting line been essential actively in geriatrics conjecture starring(p) vertebral column mechanisms of the beingness agedness at the main(a) changes in the neuro - endocrinal frame , which may tend to utility(prenominal) changes in tissues. In this aspect , the introductory effect of exertion changes the particular means of a mooring secretory organ ( hypophysis , thyroid , or , in particular , gonads , etc.) are replacement the check that agedness does non change the function of any one cancer and all neuro- inborn discrimination gland situation organism.\n fair astray cognise hypotheses linking senescence with primary changes in the hypothalamus. Hypothalamus - section betweenbrain seed biological rhythms , contend a steer aim in the normal of the endocrine glands , which is thr ough with(p) via the rally endocrine glands - the hypophysis system gland .\n consort to the hypothesis hypothalamic hours ( Dielman , 1968, 1976) , old age is seen as a invasion of the internal surroundings of the body , associated with an append in the act of the hypothalamus. As a result, the sr. dramatically increase secretion of hypothalamic hormones ( liberinov ) and a occur of pituitary hormones ( gonadotropins , growth hormone ) and insulin. However, along with the excitant of some hypothalamic structures other aging reduces its activity, which leads to a deregulation of many a(prenominal) sides and communion functions.'